Resveratrol is mainly derived from peanuts, grapes, knotweed, mulberries and other plants. Resveratrol, a non-flavonoid polyphenol organic compound, is an antitoxin produced when many plants are stimulated.
Natural resveratrol has two structures, cis and trans. In nature, it mainly exists in trans conformation. The two structures can be combined with glucose to form cis and trans resveratrol glycosides. The cis and trans resveratrol glycosides can release resveratrol under the action of glycosidases in the intestine. Under ultraviolet light, trans-resveratrol can be converted into cis-isomer.
The content of resveratrol in natural organisms is not high, and it can be transformed through various methods. It is generally formed by acid-base hydrolysis and biological transformation.
The conversion of resveratrol by acid-base hydrolysis is mainly to convert resveratrol glycosides in plants into aglycones, usually by acid hydrolysis or alkaline hydrolysis, but acid-base hydrolysis generally requires high temperature and high pressure conditions. , The required conditions are severe and the equipment requirements are high, causing certain damage to the environment.
The method of bioconversion of resveratrol has relatively mild conditions and simple operation. Therefore, enzymatic hydrolysis and microbial fermentation are generally used to convert resveratrol at this stage. In recent years, there have been many reports on the enzymatic hydrolysis of Polygonum cuspidatum, such as the use of Polygonum cuspidatum medicinal material's own enzymes, cellulase, β-glucosidase and other enzymatic hydrolysis to obtain resveratrol. The microbial fermentation method can also greatly increase the yield of resveratrol in the traditional Chinese medicine Polygonum cuspidatum. Some scholars use rhizozyme bacteria to carry out liquid fermentation of the crude extract of polydatin to convert polydatin into resveratrol, with a conversion rate of 95.8%.
The functions of resveratrol are:
1. Anti-tumor effect. Resveratrol is a natural anti-tumor chemopreventive agent. It has good anti-cancer activity in the 3 stages of tumorigenesis, initiation, enhancement and expansion, and has an inhibitory effect on cancer cells in each stage. .
2. Protective effect on cardiovascular and cerebrovascular. Resveratrol can reduce myocardial ischemia-reperfusion injury, inhibit the formation of atherosclerosis and thrombus, anti-inflammatory, anti-oxidation, and relax blood vessels to exert its protective effects on cardiovascular and cerebrovascular.
3. Anti-oxidation and anti-free radicals. Resveratrol can scavenge and inhibit the generation of free radicals, inhibit lipid peroxidation, and regulate the activity of antioxidant enzymes.
4. Regulating the immune system. Resveratrol can increase the phagocytosis rate of macrophages in the body. Studies have found that resveratrol also has anti-viral, anti-aging, anti-allergic and liver-protective effects. "
